Table 2

A selection of intermediate (30%–70% association with cancer) and high-risk (above 70% association with cancer) autoantibody-mediated encephalitis39 40

Autoantibody-mediated encephalitisRelated tumour
Intermediate-risk antibodies
NMDAR
AMPAR
GABA A/B
CASPR2
mGluR5
Ovarian or extraovarian teratomas
Small cell lung cancer, malignant thymoma
Small cell lung cancer
Malignant thymoma
Hodgkin’s lymphoma
High-risk antibodies
Hu
CRMP5
Yo
Ma2
Small and non-small cell lung cancer, neuroendocrine tumours and neuroblastoma
Small cell lung cancer and thymoma
Small and non-small cell lung cancer, breast cancer
Testicular cancer, non-small cell lung cancer
  • AMPAR, α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor; CASPR2, contactin-associated protein-like 2; CRMP5, anticollapsing response-mediator protein-5; GABA, gamma-aminobutyric acid; mGluR5, metabotropic glutamate receptor 5; NMDAR, N-methyl-D-aspartate receptor; PCA2, Purkinje cell antigen 2.