Characteristics of the included studies
Authors | Original samples | Patients setting | Types of statin | Samples (matched) | PSM ratio | Age (years) | Male (%) | CVD (%) | T2DM (%) | HT (%) | Statin use | Outcome | Adjustment | NOS |
Cariou et al 20 | NR | Hospitalised | Unknown | 2449 | 1:1 | N/A | N/A | N/A | N/A | N/A | Routine. Continuation unclear | 28 days | IPTW | 8 |
Fan et al 15 | 2147 | Hospitalised | Atorvastatin (69.9) Rosuvastatin (29.6) Pravastatin (0.5%) | 512 | 1:1 | 65 | 41 | 21 | 20 | 51 | Routine and continued in-hospital | In-hospital | Multivariable Cox-regression age, gender, TC, triglyceride, LDL, procalcitonin, BNP | 8 |
Gupta et al 12 | 2626 | Hospitalised | Unknown | 1296 | 1:1 | 70 | 45 | 14 | 47 | 68 | Routine | In-hospital (30 days) | Multivariable logistic regression age, gender, comorbidities, medications | 8 |
Lee et al 16 | 10 448 | Hospitalised | All | 1599 | 1:2 | 65 | 34 | 19 | 57 | 71 | Routine. Continuation unclear | 60 days | Multivariable Cox-regression age, sex, history of comorbidities | 8 |
Oh et al 17 | 7780 | Hospitalised | Unknown | 2333 | 1:1 | N/A | N/A | N/A | N/A | N/A | Routine and continued in-hospital | In-hospital | Multivariable logistic regression factors unclear | 8 |
Peymani et al 18 | 150 | Outpatients+hospitalised | Atorvastatin (94.7) Rosuvastatin (2.7) Simvastatin (2.7) | 150 | 1:1 | 63 | 59 | 2 | 21 | 29 | Routine and continued | 27 days | Multivariable Cox-regression factors unclear | 8 |
Saeed et al 19 | 4252 | Hospitalised | Atorvastatin (76) Pravastatin (5) Rosuvastatin (1) Simvastatin (18) | 1802 | 1:1 | N/A | N/A | N/A | N/A | N/A | In-hospital | In-hospital | IPTW | 9 |
Zhang et al 13 | 13 981 | Hospitalised | Atorvastatin (83.2) Rosuvastatin (15.6) | 4305 | 1:4 | N/A | N/A | N/A | N/A | N/A | In-hospital | 28 days | Multivariable logistic regression age, gender, and SpO2 at admission | 8 |
Age, male, CVD, T2DM and HT refer to the PSM cohort.
BNP, brain natriuretic peptide; CVD, cardiovascular diseases; HT, hypertension; IPTW, inverse probability of treatment weighting; LDL, low-density lipoprotein; N/A, not applicable/available; NOS, Newcastle-Ottawa Scale; PSM, propensity-score matching; SpO2, O2 saturation; TC, total cholestrol; T2DM, type 2 diabetes mellitus.