Table 1

Single antiplatelet therapy Single antiplatelet therapy (SAPT)

IndicationTherapyDuration of therapyGuideline
Cerebrovascular accident or Transient Ischaemic Attack >21 days agoFirst-choice: Clopidogrel*
Second choice: ASA +dipyridamole
Third choice: ASA
Lifelong*2019 FMS Herseninfarct en hersenbloeding7
(Cerebral infarction and cerebral haemorrhage)
Coronary artery disease/Stable AnginaASALifelong*2013 ESC Guidelines on the management of stable coronary artery disease8
Acute coronary syndrome or PCI >1 yearClopidogrel or ASALifelong*2017 ESC focused update on dual antiplatelet therapy in coronary artery disease9
CABG in stable CAD settingClopidogrel or ASALifelong*2017 ESC focused update on dual antiplatelet therapy in coronary artery disease9
TAVI procedure with high bleeding riskClopidogrel or ASALifelong*2017 ESC/EACTS Guidelines for the management of valvular heart disease10
TAVI procedure >3–6 months agoClopidogrel or ASALifelong*2017 ESC/EACTS Guidelines for the management of valvular heart disease10
Aortic bioprosthesis or valve sparing surgeryASA3 months2017 ESC/EACTS Guidelines for the management of valvular heart disease10
Surgical implantation of a mitral or tricuspid bioprothesis
>3 months ago
ASALifelong*2017 ESC/EACTS Guidelines for the management of valvular heart disease10
Surgical mitral or tricuspid valve repair
>3 months ago
ASALifelong*2017 ESC/EACTS Guidelines for the management of valvular heart disease10
Peripheral arterial diseaseClopidogrel or ASALifelong*2017 ESVS/ESC Guidelines on the diagnosis and treatment of peripheral arterial diseases11,12
Carotid stenosisClopidogrel or ASALifelong*2019 FMS Herseninfarct en hersenbloeding7
(Cerebral infarction and cerebral haemorrhage)
Carotid stenosis stenting >6 months agoClopidogrel or ASALifelong*2017 ESVS/ESC Guidelines on the diagnosis and treatment of peripheral arterial diseases11,12
Peripheral percutaneous revascularisation >1 month agoClopidogrel or ASALifelong*2017 ESVS/ESC Guidelines on the diagnosis and treatment of peripheral arterial diseases11,12
Below the knee bypass with prosthetic graft >1 year agoClopidogrel or ASALifelong*2017 ESVS/ESC Guidelines on the diagnosis and treatment of peripheral arterial diseases11,12
Venous bypassClopidogrel or ASALifelong*2017 ESVS/ESC Guidelines on the diagnosis and treatment of peripheral arterial diseases11,12
  • *Lifelong indication, unless patients develop an indication for a therapeutic anticoagulation therapy. In these cases, the antithrombotic therapy for patients must be evaluated in terms of whether antiplatelet therapy is still indicated.

  • ASA, acetylsalicylic acid; CABG, coronary artery bypass grafting; CAD, coronary artery disease; EACTS, European Society of Cardio-Thoracic Surgery; ESC, European Society of Cardiology; ESVS, European Society of Vascular Surgery; FMS, Federatie Medisch Specialisten (Federation of Medical specialists); PCI, percutaneous coronary intervention; TAVI, transcatheter aortic valve implantation.