Table 1

Characteristics of patients in the derivation and validation cohort

CharacteristicsDerivation cohortValidation cohortP value
Total (n)746248
Age (years)58.21±13.0858.35±13.320.780§
Intravenous thrombolysis (rt-PA)86(11.5%)32(12.9%)0.562*
Baseline NIHSS2(0, 3)2(0, 4)0.791‡
Diabetes mellitus192(25.7%)50(20.2%)0.076*
Coronary heart disease63(8.4%)25(10.1%)0.432*
Atrial fibrillation22(2.9%)3(1.2%)0.130†
Index events (TIA)55(7.4%)20(8.1%)0.721*
Baseline SBP (mmHg)149.05±24.62148.17±23.580.512§
Baseline DBP (mmHg)89.85±15.5390.01±16.050.399§
FBG (mmol/L)5.7(4.9, 7.5)5.5(4.9, 7.2)0.184‡
HBA1c (%)6.0(5.6, 6.7)5.8(5.6, 6.4)0.243‡
hs-CRP (mg/dL)1.6(0.6, 4.0)1.6(0.6, 3.6)0.652‡
WBC (×109/L)7.2(6.0, 8.7)7.0(5.9, 8.9)0.366‡
Hcy (μmol/L)13.0(10.2, 16.1)13.1(10.1, 16.9)0.347‡
SUA (μmol/L)354.32±101.55363.57±114.720.061§
LDL-C (mmol/L)3.0(2.4, 3.5)2.9(2.3, 3.6)0.673‡
mRS≥2 at 3 months147(19.7%)56(22.6%)0.330*
  • *Pearson’s χ2 test.

  • †Fisher test.

  • ‡Mann-Whitney U test.

  • §t-Test.

  • Data are shown as numbers(%) or mean±SD) or medians (IQRs).

  • No significant differences in these variables between the derivation and validation cohort.

  • Baseline DBP, diastolic blood pressure at admission; baseline NIHSS, NIHSS at admission;baseline SBP, systolic blood pressure at admission; FBG, fasting blood glucose; HBA1c, haemoglobin A1c; Hcy, homocysteine; hs-CRP, high-sensitivity C reactive protein; LDL-C, low-density lipoprotein cholesterol; mRS, modified Rankin Scale; NIHSS, National Institute of Health Stroke Scale; pre-mRS, premorbid mRS; rt-PA, recombinant human tissue-type plasminogen; SUA, serum uric acid; TIA, transient ischaemic attack; WBC, white blood cell.