Characteristics of patients in the derivation and validation cohort
| Characteristics | Derivation cohort | Validation cohort | P value |
|---|---|---|---|
| Total (n) | 746 | 248 | |
| Female | 229(30.7%) | 71(28.6%) | 0.539* |
| Age (years) | 58.21±13.08 | 58.35±13.32 | 0.780§ |
| Pre-mRS=1 | 74(9.9%) | 25(10.1%) | 0.942* |
| Intravenous thrombolysis (rt-PA) | 86(11.5%) | 32(12.9%) | 0.562* |
| Baseline NIHSS | 2(0, 3) | 2(0, 4) | 0.791‡ |
| Diabetes mellitus | 192(25.7%) | 50(20.2%) | 0.076* |
| Hypertension | 433(58.0%) | 142(57.3%) | 0.828* |
| Coronary heart disease | 63(8.4%) | 25(10.1%) | 0.432* |
| Atrial fibrillation | 22(2.9%) | 3(1.2%) | 0.130† |
| Index events (TIA) | 55(7.4%) | 20(8.1%) | 0.721* |
| Baseline SBP (mmHg) | 149.05±24.62 | 148.17±23.58 | 0.512§ |
| Baseline DBP (mmHg) | 89.85±15.53 | 90.01±16.05 | 0.399§ |
| FBG (mmol/L) | 5.7(4.9, 7.5) | 5.5(4.9, 7.2) | 0.184‡ |
| HBA1c (%) | 6.0(5.6, 6.7) | 5.8(5.6, 6.4) | 0.243‡ |
| hs-CRP (mg/dL) | 1.6(0.6, 4.0) | 1.6(0.6, 3.6) | 0.652‡ |
| WBC (×109/L) | 7.2(6.0, 8.7) | 7.0(5.9, 8.9) | 0.366‡ |
| Hcy (μmol/L) | 13.0(10.2, 16.1) | 13.1(10.1, 16.9) | 0.347‡ |
| SUA (μmol/L) | 354.32±101.55 | 363.57±114.72 | 0.061§ |
| LDL-C (mmol/L) | 3.0(2.4, 3.5) | 2.9(2.3, 3.6) | 0.673‡ |
| mRS≥2 at 3 months | 147(19.7%) | 56(22.6%) | 0.330* |
*Pearson’s χ2 test.
†Fisher test.
‡Mann-Whitney U test.
§t-Test.
Data are shown as numbers(%) or mean±SD) or medians (IQRs).
No significant differences in these variables between the derivation and validation cohort.
Baseline DBP, diastolic blood pressure at admission; baseline NIHSS, NIHSS at admission;baseline SBP, systolic blood pressure at admission; FBG, fasting blood glucose; HBA1c, haemoglobin A1c; Hcy, homocysteine; hs-CRP, high-sensitivity C reactive protein; LDL-C, low-density lipoprotein cholesterol; mRS, modified Rankin Scale; NIHSS, National Institute of Health Stroke Scale; pre-mRS, premorbid mRS; rt-PA, recombinant human tissue-type plasminogen; SUA, serum uric acid; TIA, transient ischaemic attack; WBC, white blood cell.