Table 2

Selected drugs that can cause QT prolongation15 33

High riskSome riskRisk not categorised*

  • Antiarrhythmics, class Ia (ajmaline, cibenzoline, disopyramide, hydroquinidine, procainamide, quinidine)

  • Antiarrhythmics, class III (amiodarone, azimilide, cibenzoline, dofetilide, dronedarone, ibutilide, sotalol, vernakalant)

  • Arsenic trioxide

  • Artemisinin derivatives (artemisinin, artemether/lumefantrine, artenimol)

  • Halofantrine

  • Haloperidol

  • Ketanserin

  • Mesoridazine

  • Panobinostat

  • Pimozide

  • Ribociclib

  • Sertindole

  • Thioridazine

  • Vandetanib

  • Amisulpride

  • Anagrelide

  • Bedaquiline

  • Bosutinib

  • Cabozanitib

  • Chlorpromazine

  • Citalopram

  • Crizotinib

  • Dasatinib

  • Delamanid

  • Domperidone

  • Dolasetron

  • Droperidol

  • Efavirenz

  • Eribulin

  • Escitalopram

  • Fluconazole

  • Gatifloxacin

  • Hydroxyzine

  • Iloperidone

  • Lapatinib

  • Levomepromazine

  • Methadone

  • Moxifloxacin

  • Nilotinib

  • Ondansetron

  • Paliperidone

  • Pasireotide

  • Pazopanib

  • Quinine

  • Ranolazine

  • Romidepsin

  • Saquinavir boosted with ritonavir

  • Sildenafil

  • Sorafenib

  • Sparfloxacin

  • Sultopride

  • Sunitinib

  • Telaprevir

  • Tolterodine

  • Toremifene

  • Tricyclics

  • Vardenafil

  • Voriconazole

  • Ziprasidone

  • Amifampridine

  • Androgen antagonists (abiraterone, bicalutamide, enzalutamide, flutamide, nilutamide)

  • Anthracyclines

  • Apomorphine

  • Asenapine

  • Atomoxetine

  • Azithromycin

  • Boceprevir

  • Brompendol

  • Ciprofloxacin

  • Clarithromycin

  • Clofazimine

  • Chloroquine

  • Clozapine

  • Erythromycin

  • Foscarnet

  • Gonadorelin analogues (buserelin, goserelin, histrelin, leuprorelin, triptorelin)

  • Gonadorelin antagonists (degarelix)

  • Levofloxacin

  • Lithium

  • Lofexidine

  • Oxaliplatin

  • Olanzapine

  • Oxytocin

  • Pentamidine (intravenous)

  • Piperaquine

  • Quetiapine

  • Rilpivirine

  • Risperidone

  • Sodium stibogluconate

  • Solifenacin

  • Spiramycin

  • Sulpiride

  • Tacrolimus

  • Telavancin

  • Telithromycin

  • Terlipressin

  • Tizanidine

  • Trazodone

  • Venlafaxine

  • Vinflunine

  • Zotepine

  • Zuclopentixol

  • *Drugs with less clear evidence of the risk of QT prolongation.

  • These lists are not exhaustive. Furthermore, other drugs (not included here) do not themselves prolong the QT interval but potentiate the effect of drugs that do. More information can be found online.15 33.