Migraine risk and analyses by demographic characteristics and comorbidities among patients with or without keloids
Variables | Keloids cohort | Non-keloids cohort | Compared with non- keloids cohort | |||
Migraine | Rate* | Migraine | Rate* | Crude HR (95% CI) | Adjusted HR† (95% CI) | |
Overall | 103 | 1.81 | 323 | 0.55 | 3.57 (2.82 to 4.52)‡ | 2.29 (1.80 to 2.92)‡ |
Gender | ||||||
Men | 19 | 0.88 | 68 | 0.30 | 3.16 (1.85 to 5.40)‡ | 2.02 (1.17 to 3.51)§ |
Women | 84 | 2.37 | 255 | 0.69 | 3.69 (2.84 to 4.79)‡ | 2.37 (1.81 to 3.10)‡ |
Stratify by age | ||||||
18–49 | 84 | 1.71 | 213 | 0.42 | 4.35 (3.34 to 5.67)‡ | 2.65 (2.02 to 3.47)‡ |
>50 | 19 | 2.43 | 110 | 1.25 | 2.13 (1.29 to 3.49)§ | 1.46 (0.88-2.39)¶ |
Comorbidity** | ||||||
No | 10 | 0.48 | 41 | 0.12 | 4.21 (2.09 to 8.44)‡ | 3.49 (1.74 to 7.02)‡ |
Yes | 93 | 2.55 | 282 | 1.06 | 2.57 (2.01 to 3.30)‡ | 2.16 (1.68 to 2.78)‡ |
*Rate, per 1000 person-years.
†Calculated by multivariate Cox proportional hazard regression model.
‡p<0.001.
§p<0.05.
¶P: non-significant.
**Patients with any examined comorbidities were classified as the comorbidity group.