Table 2

Comparison of cortisol responses to ACTH at 30 and 60 min. These data show that there is a proportion of patients who will be diagnosed as AI if only 30 min sample was used

Group A—patients on steroids—total 120 patients (30.5%)
60 min measurement
Insufficient responseNormal response
30 min measurementInsufficient response51 (42.5%)8 (6.7%)
(Late responders)
Normal response0 (0.0%)61 (50.8%)
Group B—patients not on steroids—total 273 patients (69.5%)
60 min measurement
Insufficient responseNormal response
30 min measurementInsufficient response10 (3.7%)11 (4.0%)
(Late responders)
Normal response0 (0.0%)252 (92.3%)
All patients—total 393 patients (100%)
60 min measurement
Insufficient responseNormal response
30 min measurementInsufficient response61 (15.5%)19 (4.8%)
(Late responders)
Normal response0 (0.0%)313 (79.6%)
  • AI, adrenal insufficiency.