Table 3

Adjusted p value of multi-factor meta-regression analysis for the efficacy and safety of low dose ticagrelor in patients with acute coronary syndrome

CovariateMACELVEFLVDDMajor bleeding eventsMinor or minimal bleeding eventsNon-bleeding adverse eventsPAgRPRU
Average age0.800.490.200.970.200.850.420.74
Region1.00NRNR1.000.830.22NR0.98
Follow-up0.520.640.270.970.650.510.24NR
Ticagrelor dose0.751.000.041.000.780.980.020.24
LanguageNRNRNR1.000.990.17NRNR
  • Monte Carlo permutation test for meta-regression correction (permutations=10 000).

  • LVDD, Left ventricular end diastolic dimension; LVEF, Left ventricular ejection fraction; MACEs, Major adverse cardiac events; NR, Not reported; PAgR, platelet aggregation rate; PRU, Platelet reaction units.