Table 3

Summary of reported outcomes in RCTs conducted on adults and children

Serial numberAuthors and yearALTASTBMISteatosisInflammationBallooningFibrosisHistological improvements
RCTs on adult population
1Harrison et al, 200312 NRNRNR
2Sanyal et al, 201015
3Foster et al, 201113 NRNRNRNRNRNR
4Hoofnagle et al, 201314 NRNR
5Aller et al, 20151 NRNRNR
Significant results 4 2 2 2 2 2 1 1
Insignificant results 1 2 1 1 1 3 1
Not reported (NR) 1 2 2 2 3 1 3
RCTs on children
1Vajro et al, 200418 NRNR
2Nobili et al, 200616 NR
3Nobili et al, 200817
4Levine et al, 20116
Significant results 1 1 1 0 0 1 0 0
Insignificant results 3 2 3 4 4 2 4 3
Not reported (NR) 1 1 1
  • ✓, Significant results; ✗, insignificant results.

  • ALT, alanine transaminase; AST, aspartate transaminase; BMI, body mass index; RCT, randomised controlled trial.