Summary of reported outcomes in RCTs conducted on adults and children
| Serial number | Authors and year | ALT | AST | BMI | Steatosis | Inflammation | Ballooning | Fibrosis | Histological improvements |
| RCTs on adult population | |||||||||
| 1 | Harrison et al, 200312 | ✓ | ✗ | ✓ | NR | ✗ | NR | ✓ | NR |
| 2 | Sanyal et al, 201015 | ✓ | ✓ | ✗ | ✓ | ✓ | ✓ | ✗ | ✓ |
| 3 | Foster et al, 201113 | ✗ | ✗ | NR | NR | NR | NR | NR | NR |
| 4 | Hoofnagle et al, 201314 | ✓ | NR | NR | ✓ | ✓ | ✓ | ✗ | ✗ |
| 5 | Aller et al, 20151 | ✓ | ✓ | ✓ | ✗ | NR | NR | ✗ | NR |
| Significant results | 4 | 2 | 2 | 2 | 2 | 2 | 1 | 1 | |
| Insignificant results | 1 | 2 | 1 | 1 | 1 | – | 3 | 1 | |
| Not reported (NR) | – | 1 | 2 | 2 | 2 | 3 | 1 | 3 | |
| RCTs on children | |||||||||
| 1 | Vajro et al, 200418 | ✗ | NR | ✗ | ✗ | ✗ | NR | ✗ | ✗ |
| 2 | Nobili et al, 200616 | ✓ | ✓ | ✓ | ✗ | ✗ | ✗ | ✗ | NR |
| 3 | Nobili et al, 200817 | ✗ | ✗ | ✗ | ✗ | ✗ | ✗ | ✗ | ✗ |
| 4 | Levine et al, 20116 | ✗ | ✗ | ✗ | ✗ | ✗ | ✓ | ✗ | ✗ |
| Significant results | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | |
| Insignificant results | 3 | 2 | 3 | 4 | 4 | 2 | 4 | 3 | |
| Not reported (NR) | – | 1 | – | – | – | 1 | – | 1 | |
✓, Significant results; ✗, insignificant results.
ALT, alanine transaminase; AST, aspartate transaminase; BMI, body mass index; RCT, randomised controlled trial.