Summary of reported outcomes in RCTs conducted on adults and children
Serial number | Authors and year | ALT | AST | BMI | Steatosis | Inflammation | Ballooning | Fibrosis | Histological improvements |
RCTs on adult population | |||||||||
1 | Harrison et al, 200312 | ✓ | ✗ | ✓ | NR | ✗ | NR | ✓ | NR |
2 | Sanyal et al, 201015 | ✓ | ✓ | ✗ | ✓ | ✓ | ✓ | ✗ | ✓ |
3 | Foster et al, 201113 | ✗ | ✗ | NR | NR | NR | NR | NR | NR |
4 | Hoofnagle et al, 201314 | ✓ | NR | NR | ✓ | ✓ | ✓ | ✗ | ✗ |
5 | Aller et al, 20151 | ✓ | ✓ | ✓ | ✗ | NR | NR | ✗ | NR |
Significant results | 4 | 2 | 2 | 2 | 2 | 2 | 1 | 1 | |
Insignificant results | 1 | 2 | 1 | 1 | 1 | – | 3 | 1 | |
Not reported (NR) | – | 1 | 2 | 2 | 2 | 3 | 1 | 3 | |
RCTs on children | |||||||||
1 | Vajro et al, 200418 | ✗ | NR | ✗ | ✗ | ✗ | NR | ✗ | ✗ |
2 | Nobili et al, 200616 | ✓ | ✓ | ✓ | ✗ | ✗ | ✗ | ✗ | NR |
3 | Nobili et al, 200817 | ✗ | ✗ | ✗ | ✗ | ✗ | ✗ | ✗ | ✗ |
4 | Levine et al, 20116 | ✗ | ✗ | ✗ | ✗ | ✗ | ✓ | ✗ | ✗ |
Significant results | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | |
Insignificant results | 3 | 2 | 3 | 4 | 4 | 2 | 4 | 3 | |
Not reported (NR) | – | 1 | – | – | – | 1 | – | 1 |
✓, Significant results; ✗, insignificant results.
ALT, alanine transaminase; AST, aspartate transaminase; BMI, body mass index; RCT, randomised controlled trial.