Impact of vitamin E on ALT, AST, BMI and steatosis score in trials
Author and year | Outcomes with respect to control and intervention group | |||||||||||
ALT (U/L) | AST (U/L) | BMI (kg/m²) | Steatosis score | |||||||||
Intervention | Control | P value | Intervention | Control | P value | Intervention | Control | P value | Intervention | Control | P value | |
Harrison et al , 200312 | −12.3 | −31 | 0.007 | * | * | NR | −1.1 | −1.6 | 0.012 | NR | NR | NR |
Vajro et al , 200418 | −31.90† −24.09‡ | −26.36† −29.9 2‡ | 0.54† 0.6 6‡ | NR | NR | NR | NR | NR | NR | * | * | NR |
Nobili et al , 200616 | −36.35 | −24.44 | 0.0001 | −13.95 | −10.05 | 0.001 | −2.39 | −1.83 | 0.0001 | § | § | NR |
Nobili et al , 200817 | −31 | −29 | 0.6 | −12 | −15 | 0.6 | −3.7 | −3.1 | 0.4 | −1 | 0 | 0.07 |
Sanyal et al, 201015 | −37 | −20.1 | 0.001 | −21.3 | −3.8 | <0.001 | 0.1 | 0.4 | 0.50 | −1.026 | −0.589 | 0.005 |
Lavine et al, 20116 | −48.3 | −35.2 | 0.07 | −22.8 | −20.4 | 0.32 | −0.03 | −0.01 | 0.78 | −0.621 | −0.399 | 0.18 |
Foster et al, 201113 | * | NR | NR | * | NR | NR | NR | NR | NR | Decreased based on abdominal CT scan | NR | NR |
Hoofnagle et al , 201314 | −21.6 | −5.1 | NR | NR | NR | NR | NR | ¶ | NR | −0.7 | −0.7 | Vitamin E=<0.001 Placebo=<0.001 |
Aller et al , 20151 | −3.7 | −16.1 | <0.05 | −1 | −5.6 | <0.05 | −5.1 | −2.9 | <0.05 | * | * | NR |
(−) Improvement in the outcome (mean response value − mean baseline value).
*Non-significant.
†Evaluation at month 2; this p value indicates difference between control and intervention group.
‡Evaluation at month 5; this p value indicates difference between control and intervention group.
§Steatosis was present in all biopsies, mostly macrovesicular, but frequently associated with microvesicular steatosis.
¶Significant improvement.
ALT, alanine transaminase; AST, aspartate transaminase; BMI, body mass index; NR, not reported.