Table 1

Correlation of clinical and laboratory variables with risk of bleeding in ITP

Clinical/Laboratory findingsRisk of bleedingComments
Bleeding symptoms present vs absent at diagnosis5 18% vs 0.8% per patient-yearIncidence rates of major bleeding.
Retrospective study.
History of haemorrhage vs none5 OR 27.5, p<0.005Retrospective study.
Age in years5
40–60 vs <40
>60 vs <40
OR 2.8, p=not significant
OR 28.9, p<0.01
Retrospective study.
Absolute immature platelet fraction12 r=−0.34 to 0.60, p<0.005Moderate to strong inverse correlation with bleeding scores.
Prospective study.
Maximum amplitude/maximum clot firmness on thromboelastography12 r=−0.26 to 0.28, p<0.05Moderate inverse correlation with bleeding scores when platelet count <60 000/mm3.
Prospective study.
  • ITP, immune thrombocytopaenia; r, Spearman’s rank correlation coefficient.