Table 2

Incidence of subsequent demyelinating diseases of the central nervous system, rather than multiple sclerosis, stratified by severity of septicaemia

NEventPYsRateCrude HR (95% CI)Adjusted HR (95% CI)
All
 Comparison group1 892 82513612 352 7801.10Reference groupReference group
 Septicaemia482 7811442 082 9006.915.99 (4.73 to 7.58)***4.17 (3.21 to 5.4)***
Length of stay due to septicaemia*
 Comparisons1 892 82513612 352 7801.10Reference groupReference group
 1–5 days91 28916523 5153.062.73 (1.63 to 4.59)***2.17 (1.27 to 3.69)***
 >5 days391 4921281 559 3858.217.06 (5.54 to 9.01)***4.73 (3.62 to 6.18)**
 P for trend<0.0001<0.0001
Severity of septicaemia
 Comparisons1 892 82513612 352 7801.10Reference groupReference group
 Mild (T1)144 548141 115 2821.261.12 (0.64 to 1.93)0.83 (0.47 to 1.45)
 Moderate (T2)145 16034657 7785.174.92 (3.36 to 7.19)***3.35 (2.25 to 4.98)***
 Severe (T3)193 07396309 84031.028.5 (21.4 to 38.0)***18.7 (13.7 to 25.6)***
 P for trend<0.0001<0.0001
  • Models adjusted for age, sex and comorbidities listed in table 1. Severity = (total length of hospital stay due to septicaemia during the follow-up duration) ÷ (length of follow-up duration). T1, the first tertile:<0.44%; T2, the second tertile: 0.44%–1.58%; T3 the third tertile:>1.58%.

  • **p<0.01; ***p<0.001.

  • *The first time hospitalisation due to septicaemia.

  • PYs, person-years;Rate, incidence rate, per 100 000 person-years.