Table 3

Subgroup analysis of FGF-21 level in T2DM

Stratification group N SMD (95% CI)Heterogeneity testPublication bias
Q p Value I 2 (%) t p Value
Total111.34 (0.70 to 1.98)286.50<0.00196.501.530.161
BMI
 BMI≥2542.22 (0.42 to 4.02)215.84<0.00198.6020.290.285
 BMI <2570.87 (0.46 to 1.29)48.40<0.00187.60−1.920.785
Combined111.34 (0.70 to 1.98)286.50<0.00196.501.530.161
Race
 Caucasian40.85 (0.17 to 1.53)34.18<0.00191.20−9.660.394
 Non-Caucasian71.64 (0.68 to 2.60)250.05<0.00197.6019.090.071
 Combined111.34 (0.70 to 1.98)286.50<0.00196.501.530.161
Measurement options
 ELISA71.68 (0.72 to 2.65)252.03<0.00197.6018.990.068
 RIA41.77 (0.55 to 1.40)29.04<0.00189.70−11.500.251
Combined111.34 (0.70 to 1.98)286.50<0.00196.501.530.161
TG
 TG <150 mg/dL30.29 (0.06 to 0.52)1.940.3790−0.160.976
 TG ≥150 mg/dL61.89 (0.83 to 2.94)217.91<0.00197.7017.170.158
Combined91.35 (0.57 to 2.13)282.97<0.00197.201.350.220
TC
 TC <110 mg/dL50.69 (0.17 to 1.21)37.10<0.00189.20−5.800.533
 110 mg/dL≤TC<220 mg/dL42.90 (0.92 to 4.02)215.84<0.00198.6020.290.285
 Combined91.35 (0.57 to 2.13)282.97<0.00197.201.350.220
HDL
 30 mg/dL<HDL<77 mg/dL90.84 (0.46 to 1.21)73.95<0.00189.20−8.000.237
 HDL ≥77 mg/dL12.09 (1.40 to 2.78)0
 Combined101.32 (0.64 to 2.01)283.22<0.00196.801.400.198
LDL
 LDL <120 mg/dL70.71 (0.24 to 1.18)61.14<0.00190.20−5.740.504
 LDL ≥120 mg/dL31.83 (0.67 to 3.99)170.11<0.00198.8025.000.134
Combined101.32 (0.64 to 2.01)283.22<0.00196.801.400.198
  • BMI, body mass index;ELISA, enzyme-linked immunosorbent assay; HDL, high-density lipoprotein; LDL, low-density lipoprotein; RIA, radioimmunoassay; SMD, standard mean difference; TC, total cholesterol;TG, triglycerides.