Table 1

Demographic and clinical data on 470 patients, with 556 associated bacteraemic or fungaemic episodes, who did and did not receive OPAT

 OPAT
YesNop Value*
Patients22448
Infections (Bacteraemic/fungaemic episodes)25531
Age† (years), n (%)
 16–302 (9.1)38 (8.5)0.621
 31–507 (31.8)99 (22.1)
 51–708 (36.4)156 (34.8)
 >705 (22.7)155 (34.6)
Gender†, n (%)
 Male11 (50.0)262 (58.5)0.431
 Female11 (50.0)186 (41.5)
Place of acquisition, n (%)
 CA20 (90.9)188 (35.4)<0.001
 HCA2 (9.1)198 (37.3)
  HA0143 (26.9)
  Not defined02 (0.4)
Specialty, n (%)
 Medicine22 (88.0)430 (81.0)<0.001
 Surgery2 (8.0)101 (19.0)
 O&G1 (4.0)0 (0.0)
Sites of infection, n (%)
 CVC (uncomplicated)0.129
  Tunnelled033 (6.2)
  Non-tunelled2 (8.7)27 (5.1)
 CVC‡ (complicated/metastatic spread)2 (8.0)21 (4.1)
 Peripheral cannula1 (0.2)
 Urinary tract (catheter-associated)58 (10.9)
 Urinary tract§ (non-catheter-associated)11 (44.0)146 (27.5)
 Biliary tract3 (12.0)51 (9.6)
 GI¶ tract3 (12.0)32 (6.0)
 GU tract9 (1.7)
 Liver abscess9 (1.7)
 LRT (non-ventilator-associated)35 (7.0)
 LRT (ventilator-associated)4 (0.8)
 Skin and soft tissue infection3 (12.0)26 (4.9)
 Peripheral joints (native)1 (4.0)2 (0.4)
 Peripheral joints (prosthetic)1 (0.2)
 Meningitis3 (0.6)
 Not defined73 (13.8)
Mortality, n (%)
 Inpatient022 (4.9)0.287
 7-day012 (2.7)0.437
 30-day024 (5.4)0.265
  • One patient had a bacteraemic and non-bacteraemic episode, so this was recorded in both groups.

  • 2 test.

  • †Patient-specific variables. Age and gender were reported as a percentage of patients.

  • ‡Complicated CVC or metastatic infections occurred only in renal haemodialysis patients. This included vertebral column, infective endocarditis and pacemaker infection.

  • §Two were complicated lower UTIs, one postprostatic biopsy.

  • ¶Enteric fevers (2×S. paratyphi and 1×S. typhi).

  • **Metastatic complication of fistula site and catheter-associated UTIs in renal haemodialysis patients.

  • CA, community-acquired; CVC, central venous catheter; GI, gastrointestinal; GU, genito-urinary; HA, hospital-acquired; HCA, health-care associated; LRT, lower respiratory tract; O&G, obstetrics and gynaecology; OPAT, outpatient parenteral antibiotic treatment; UTIs, urinary tract infections.