Demographic and clinical data on 470 patients, with 556 associated bacteraemic or fungaemic episodes, who did and did not receive OPAT
| OPAT | |||
|---|---|---|---|
| Yes | No | p Value* | |
| Patients | 22 | 448 | |
| Infections (Bacteraemic/fungaemic episodes) | 25 | 531 | |
| Age† (years), n (%) | |||
| 16–30 | 2 (9.1) | 38 (8.5) | 0.621 |
| 31–50 | 7 (31.8) | 99 (22.1) | |
| 51–70 | 8 (36.4) | 156 (34.8) | |
| >70 | 5 (22.7) | 155 (34.6) | |
| Gender†, n (%) | |||
| Male | 11 (50.0) | 262 (58.5) | 0.431 |
| Female | 11 (50.0) | 186 (41.5) | |
| Place of acquisition, n (%) | |||
| CA | 20 (90.9) | 188 (35.4) | <0.001 |
| HCA | 2 (9.1) | 198 (37.3) | |
| HA | 0 | 143 (26.9) | |
| Not defined | 0 | 2 (0.4) | |
| Specialty, n (%) | |||
| Medicine | 22 (88.0) | 430 (81.0) | <0.001 |
| Surgery | 2 (8.0) | 101 (19.0) | |
| O&G | 1 (4.0) | 0 (0.0) | |
| Sites of infection, n (%) | |||
| CVC (uncomplicated) | 0.129 | ||
| Tunnelled | 0 | 33 (6.2) | |
| Non-tunelled | 2 (8.7) | 27 (5.1) | |
| CVC‡ (complicated/metastatic spread) | 2 (8.0) | 21 (4.1) | |
| Peripheral cannula | 1 (0.2) | ||
| Urinary tract (catheter-associated) | 58 (10.9) | ||
| Urinary tract§ (non-catheter-associated) | 11 (44.0) | 146 (27.5) | |
| Biliary tract | 3 (12.0) | 51 (9.6) | |
| GI¶ tract | 3 (12.0) | 32 (6.0) | |
| GU tract | 9 (1.7) | ||
| Liver abscess | 9 (1.7) | ||
| LRT (non-ventilator-associated) | 35 (7.0) | ||
| LRT (ventilator-associated) | 4 (0.8) | ||
| Skin and soft tissue infection | 3 (12.0) | 26 (4.9) | |
| Peripheral joints (native) | 1 (4.0) | 2 (0.4) | |
| Peripheral joints (prosthetic) | 1 (0.2) | ||
| Meningitis | 3 (0.6) | ||
| Not defined | 73 (13.8) | ||
| Mortality, n (%) | |||
| Inpatient | 0 | 22 (4.9) | 0.287 |
| 7-day | 0 | 12 (2.7) | 0.437 |
| 30-day | 0 | 24 (5.4) | 0.265 |
One patient had a bacteraemic and non-bacteraemic episode, so this was recorded in both groups.
*χ2 test.
†Patient-specific variables. Age and gender were reported as a percentage of patients.
‡Complicated CVC or metastatic infections occurred only in renal haemodialysis patients. This included vertebral column, infective endocarditis and pacemaker infection.
§Two were complicated lower UTIs, one postprostatic biopsy.
¶Enteric fevers (2×S. paratyphi and 1×S. typhi).
**Metastatic complication of fistula site and catheter-associated UTIs in renal haemodialysis patients.
CA, community-acquired; CVC, central venous catheter; GI, gastrointestinal; GU, genito-urinary; HA, hospital-acquired; HCA, health-care associated; LRT, lower respiratory tract; O&G, obstetrics and gynaecology; OPAT, outpatient parenteral antibiotic treatment; UTIs, urinary tract infections.