Studies that have evaluated histological markers that discriminate eosinophilic oesophagitis from GORD
| Eosinophilic oesophagitis | GORD | Adult/child | Correlation | Reference | |
|---|---|---|---|---|---|
| Intraepithelial eosinophils* | 55 (±27.5) | 6.9 (±9.7) | Children | p<0.0001 | 62 |
| MBP† | 1479 (±1290) | 59 (±103) | Adult | p<0.001 | 46 |
| Eotaxin-3† | 2219 (±1782) | 479 (±777) | Adult | p=0.01 | 46 |
| Intraepithelial mast cells* | 26.3 (±12.7) | 7.8 (±8.9) | Children | p<0.0001 | 62 |
| TGF-β positive cells in LP* | 126 (61–191) | 9 (2−24) | Children | p=0.002 | 31 |
| COX-2‡ | 0 | 0.5** | Adult | p<0.01 | 69 |
The table summarises studies that have assessed potential laboratory markers to discriminate eosinophil oesophagitis from GORD.
*Per high powered field
†Maximum staining density, cells/mm2 (±SD)
‡Monoclonal antibody uptake grading.
**Faint stain in basal layer of epithelium.
COX, cyclo-oxygenase; GORD, gastric oesophageal reflex disease; LP, lamina propria; MBP, major basic protein; TGF-β, transforming growth factor β.