Table 2

Clinical characteristics associated with genetic variations in AD

Clinical characteristicsGenetic variants
Age of onset of ADAPOE4, A2M, LRP, glutathione S-transferase, IL-1, IDE, SORL1, PGBD1, EDF3
Accelerated cognitive declineAPOE4, IL-1, IDE
Aggressive behaviourCOMT gene, serotonin transporter 5-HTTLPR polymorphism, dopamine receptor genes (DRD1 and DRD3)
Poor response/more adverse effects to cholinesterase inhibitorsAPOE4-4, PS2 genotype, CYP2D6 genetic variant, paroxonase 1 and butrylcholinesterase (BuchE-K) polymorphic variants
  • AD, Alzheimer's disease; APOE, apolipoprotein E; IL-1, interleukin 1; PGBD1, piggy BAC transportable element derived 1; SORL1, sortilin-related receptor.