Table 1

Pharmacology of ACE inhibitors

Active metaboliteZinc ligandBioavailability (%)Half-life (h)Route of elimination
CaptoprilNoSulfhydryl75–911.7Kidney
EnalaprilYesCarboxyl6011Kidney
LisinoprilNoCarboxyl6–6012Kidney
BenazeprilYesCarboxyl>3710–11Kidney
QuinaprilYesCarboxyl>601.9–2.5 (25 terminal)Kidney
RamiprilYesCarboxyl50–60Triphasic 4, 9–18, >50Kidney
TrandolaprilYesCarboxyl7015–24Kidney, liver
MoexipirlYesCarboxyl132–9Kidney
FosinoprilYesPhosphinyl3612Liver, kidney
  • Adapted from Brown and Vaughan.9