Table 3

Genotypes and results of univariate analysis

SNP (rs No)*GenotypeLung cancerSmokingcontrolsCall rate (%)UnivariateOR (95% CI)p ValuePhenotype
α5-nAChR (rs 16969968)AA68 (16%)45 (9%)1.8 (1.2 to 2.7)0.004Susceptibility
AG/GG361 (84%)426 (91%)
CYP 2E1 (rs 2031920)TT/TC24 (6%)14 (3%)952.1 (1.0 to 4.3)0.03Susceptibility
CC379 (94%)463 (97%)
Interleukin-18 (rs 360721)CC237 (54%)208 (45%)961.4 (1.1 to 1.9)0.009Susceptibility
CG/GG201 (46%)250 (55%)
Interleukin-8 (rs 4073)TT129 (31%)109 (23%)961.5 (1.1 to 2.1)0.005Susceptibility
AT/AA284 (69%)367 (77%)
Interleukin 1B (rs 16944)GG215 (49%)212 (44%)991.2 (0.9 to 1.6)0.14Susceptibility
AA/AG224 (51%)269 (56%)
ITGA11 (rs 2306022)AA14 (3%)6 (1%)982.6 (0.9 to 7.6)0.04Susceptibility
GA/GG422 (97%)470 (99%)
N-Acetylcysteine transferase 2 (rs 1799930)GG239 (56%)222 (47%)971.4 (1.1 to 1.9)0.006Susceptibility
AA/AG189 (44%)253 (53%)
α1-AntichymotrypsinGG123 (28%)96 (20%)981.60.004Susceptibility
(rs 4934)AG/AA312 (72%)383 (80%)(1.2 to 2.2)
Cerberus 1 (rs 10115703)AA/AG71 (16%)59 (12%)971.4 (0.9 to 2.0)0.10Susceptibility
GG363 (84%)413 (88%)
DAT1 (rs 6413429)GT/TT64 (15%)50 (10%)981.5 (1.0 to 2.3)0.04Susceptibility
GG367 (85%)431 (90%)
TNFR1 (TNFRSF1A) (rs 1139417)AA148 (36%)142 (30%)961.3 (1.0 to 1.8)0.05Susceptibility
AG/GG258 (64%)329 (70%)
TLR9 (rs 5743836)CC12 (3%)6 (1%)962.2 (0.8 to 6.6)0.12Susceptibility
CT/TT419 (97%)455 (99%)
P73 (TP73) (rs 2273953)CC219 (52%)292 (62%)960.65 (0.49 to 0.85)0.001Protective
TC/TT206 (48%)178 (38%)
SOD3 (rs 1799895)GG/GC4 (1%)15 (3%)960.28 (0.10 to 0.90)0.02Protective
CC425 (99%)451 (97%)
ITGB3 (rs 2317676)GG/GA44 (10%)77 (16%)980.59 (0.39 to 0.89)0.008Protective
AA391 (90%)403 (84%)
DRD2 (rs 1799732)CDel/Del.Del70 (16%)107 (22%)980.68 (0.48 to 0.96)0.02Protective
CC359 (84%)372 (78%)
BCL2 (rs 2279115)AA103 (24%)145 (31%)970.71 (0.53 to 0.97)0.03Protective
AC/CC328 (76%)330 (69%)
XPD (ERCC2) (rs 13181)GG60 (14%)81 (18%)960.74 (0.51 to 1.10)0.11Protective
GT/TT376 (86%)377 (82%)
REV1 (REV1L) (rs 3087386)CC128 (29%)163 (34%)980.79 (0.59 to 1.10)0.10Protective
TC/TT310 (71%)312 (66%)
FasL (TNFSF6) (rs 763110)TT53 (12%)78 (16%)980.72 (0.49 to 1.10)0.09Protective
TC/CC379 (88%)403 (84%)
  • *OMIM nomenclature.

  • SNP, single nucleotide polymorphism.