Table 2

Expected genotype frequencies and Hardy–Weinberg equilibrium (HWE)

SNP NoSNP name (rs)Allele frequencies (study total = 930)HWE observed genotypes(p Value)Allele frequencies
Study controls (n = 484)Hapmap Caucasian*
MajorMinorMajorMinorMajorMinor
1A5 nAChR (rs 16969968)0.650.350.570.690.310.580.42
2CYP 2E1 (rs 2031920)0.980.020.060.990.010.940.06
3Interleukin-18 (rs 360721)0.700.300.770.680.320.700.32
4Interleukin-8 (rs 4073)0.540.460.140.510.490.600.40
5Interleukin 1B (rs 16944)0.690.310.800.670.330.650.35
6ITGA11 (rs 2306022)0.900.100.070.910.090.930.07
7NAT 2 (rs 1799930)0.710.290.870.690.310.710.29
8α1-antichymotrypsin (rs 4934)0.500.500.540.470.530.510.49
9Cerberus 1 (rs 10115703)0.920.080.540.930.070.890.11
10DAT1 (rs 6413429)0.930.070.780.940.060.870.13
11TNFR1 (rs 1139417)0.570.430.960.560.440.510.49
12TLR9 (rs 5743836)0.850.150.920.850.150.840.16
13P73 (TP73) (rs 2273953)0.750.250.930.780.220.850.15
14SOD3 (rs 1799895)0.990.010.990.980.020.970.03
15ITGB3 (rs 2317676)0.930.070.510.910.090.950.05
16DRD2 (rs 1799732)0.900.100.670.890.110.900.10
17BCL2 (rs 2279115)0.510.490.600.530.470.570.43
18XPD (ERCC2) (rs 13181)0.610.390.900.590.410.670.33
19REV1 (REV1L) (rs 3087386)0.560.440.960.580.420.500.50
20FasL (TNFSF6) (rs 763110)0.630.370.830.610.390.640.36
  • *Allele frequencies for Caucasians from www.hapmap.org.

  • SNP, single nucleotide polymorphism.