Risk stratification model to predict progression of monoclonal gammopathy of undetermined significance (MGUS) to myeloma or related disorders
| Risk group | Number of patients | Relative risk | Absolute risk of progression at 20 years (%) | Absolute risk of progression at 20 years accounting for death as a competing risk (%) |
|---|---|---|---|---|
| Reproduced with permission from Kyle and Rajkumar.3 | ||||
| Low risk serum M-protein <15 g/l, IgG type, normal free light chain ratio (0.26–1.65) | 449 | 1 | 5 | 2 |
| Low-intermediate risk (any one risk factor abnormal) | 420 | 5.4 | 21 | 10 |
| High-intermediate risk (any two risk factors abnormal) | 226 | 10.1 | 37 | 18 |
| High risk (all three risk factors abnormal) | 53 | 20.8 | 58 | 27 |