Myeloma-related organ or tissue impairment (ROTI). Based upon BCSH guidelines 2005
| CT, computed tomography; MRI, magnetic resonance imaging. | |
| Increased calcium levels | Corrected serum calcium >0.25 mmol/l above the upper limit of normal or >2.75 mmol/l |
| Renal insufficiency | Attributable to myeloma |
| Anaemia | Haemoglobin 2 g/dl below the lower limit of normal or haemoglobin <10 g/dl |
| Bone lesions | Lytic lesions or osteoporosis with compression fractures (MRI or CT may clarify) |
| Other | Symptomatic hyperviscosity, amyloidosis, recurrent bacterial infections (>2 episodes in 12 months) |