Table 2

 Myeloma-related organ or tissue impairment (ROTI). Based upon BCSH guidelines 2005

CT, computed tomography; MRI, magnetic resonance imaging.
Increased calcium levelsCorrected serum calcium >0.25 mmol/l above the upper limit of normal or >2.75 mmol/l
Renal insufficiencyAttributable to myeloma
AnaemiaHaemoglobin 2 g/dl below the lower limit of normal or haemoglobin <10 g/dl
Bone lesionsLytic lesions or osteoporosis with compression fractures (MRI or CT may clarify)
OtherSymptomatic hyperviscosity, amyloidosis, recurrent bacterial infections (>2 episodes in 12 months)