Table 2

 Effect of weight loss in non-alcoholic fatty liver disease in adults

AuthorInterventionNumberStudy TypeComparisonDuration (months)ALTHistology
SteatosisInflammationFibrosis
NA, not assessed. *No change in lobular inflammation, but significant worsening of portal inflammation; †as assessed by ultrasound; ‡significance level p = 0.053.
Ueno32Diet/exercise25Open label, non-randomisedNo treatment3ImprovedImprovedNo changeNo change
Huang29Diet/exercise23Pilot trialBaseline12No changeNo changeNo changeNo change
Andersen28Diet41Case seriesBaseline6ImprovedImprovedNo change*No change
Okita30Diet14Pilot trialBaseline6ImprovedNANANA
Palmer31Diet39Case seriesBaselineImprovedNANANA
Harrison38Orlistat10Pilot trialBaseline6ImprovedNo changeNo changeNo change
HatzitoliosA35Orlistat21Pilot trialBaseline6ImprovedNANANA
Sabuncu40Orlistat12Pilot trialBaseline6ImprovedImproved†NANA
Sibutramine13Pilot trialBaseline6ImprovedImproved†NANA
Dixon41Gastric banding36Pilot trialBaseline26ImprovedImprovedImprovedImproved
Silverman44Gastro-jejenostomy91Case seriesBaseline18No changeImprovedNo changeImproved
Luyckx43Gastric banding69Case seriesBaseline27ImprovedImprovedWorseNo change
Kral42Biliopancreatic diversion104Case seriesBaseline74ImprovedImprovedNo changeWorse‡
Clark JM92Reux-en Y gastric bypass16Case seriesBaseline10No changeImprovedImprovedImproved