Pharmacokinetics of cocaine according to the route of administration
| Route of administration | Onset of action | Peak effect | Duration of action |
|---|---|---|---|
| Inhalation (smoking) | 3–5 seconds | 1–3 minutes | 5–15 minutes |
| Intravenous | 10–60 seconds | 3–5 minutes | 20–60 minutes |
| Intranasal or mucusal | 1–5 minutes | 15–20 minutes | 60–90 minutes |
| Gastrointestinal | Up to 20 minutes | Up to 90 minutes | Up to 180 minutes |