Table 1

 Proposed causes of Darwin’s disease

Causal typeSpecific causeReference
Organic Heart diseaseDarwin himself (1831–1882)1,2 and Diary of Health
Nervous indigestionObituary (1882)2
Chronic from sea sicknessObituary (1882)4
Chronic neurastheniaJohnston, 19015
Chronic eye strainGould, 19036
Aftermath of Chilean feverLeonard Huxley, 1927, see Colp7
PyorrhoeaLeonard Darwin, 1927, see Colp7
BrucellosisSimpson, 19588
Chagas’ diseaseAdler, 19599
Metabolic diseaseStetten, 195910
Acute intermittent porphyriaWith, 1960, see King-Hele11
Diaphragmatic herniaKohn, 196312
Narcolepsy (diabetes)Roberts, 196613
Arsenic poisoningWinslow, 197114
Pigeon allergyGruber and Barrett, 1974, see Colp7
Peptic ulcerSee Colp p1307
Duodenal ulcerSee Colp p1307
Appendicitissee Colp p1307
Smouldering hepatitisSee Colp p1307
CholecystitisSee Colp p1307
Amoeba infectionSee Colp7
AllergySmith, 1990, 199215,16
Systemic lactose intoleranceCampbell and Matthews,17,18
Psycosomatic
1st pscychoanalytical theoryKemf, 191819
HypochondriaHubble, 194320
PsychoneurosisHubble, 194320
Chronic depressionAlvarez, 195921
PsychosomaticWoodruff 196522
Bereavement syndromeBolby, 1965, 199023,24
NeurosisColp, 19777
Mixed psychosomaticColp, 19777
Anxiety stateBernstein, 198225
Panic syndromeBarloon and Noyes, 199726