Proposed causes of Darwin’s disease
| Causal type | Specific cause | Reference |
|---|---|---|
| Organic | Heart disease | Darwin himself (1831–1882)1,2 and Diary of Health |
| Nervous indigestion | Obituary (1882)2 | |
| Chronic from sea sickness | Obituary (1882)4 | |
| Chronic neurasthenia | Johnston, 19015 | |
| Chronic eye strain | Gould, 19036 | |
| Aftermath of Chilean fever | Leonard Huxley, 1927, see Colp7 | |
| Pyorrhoea | Leonard Darwin, 1927, see Colp7 | |
| Brucellosis | Simpson, 19588 | |
| Chagas’ disease | Adler, 19599 | |
| Metabolic disease | Stetten, 195910 | |
| Acute intermittent porphyria | With, 1960, see King-Hele11 | |
| Diaphragmatic hernia | Kohn, 196312 | |
| Narcolepsy (diabetes) | Roberts, 196613 | |
| Arsenic poisoning | Winslow, 197114 | |
| Pigeon allergy | Gruber and Barrett, 1974, see Colp7 | |
| Peptic ulcer | See Colp p1307 | |
| Duodenal ulcer | See Colp p1307 | |
| Appendicitis | see Colp p1307 | |
| Smouldering hepatitis | See Colp p1307 | |
| Cholecystitis | See Colp p1307 | |
| Amoeba infection | See Colp7 | |
| Allergy | Smith, 1990, 199215,16 | |
| Systemic lactose intolerance | Campbell and Matthews,17,18 | |
| Psycosomatic | ||
| 1st pscychoanalytical theory | Kemf, 191819 | |
| Hypochondria | Hubble, 194320 | |
| Psychoneurosis | Hubble, 194320 | |
| Chronic depression | Alvarez, 195921 | |
| Psychosomatic | Woodruff 196522 | |
| Bereavement syndrome | Bolby, 1965, 199023,24 | |
| Neurosis | Colp, 19777 | |
| Mixed psychosomatic | Colp, 19777 | |
| Anxiety state | Bernstein, 198225 | |
| Panic syndrome | Barloon and Noyes, 199726 |