Table 2

 Features of large duct and small duct chronic pancreatitis

FeatureLarge ductSmall duct
Sex predominanceMaleFemale
Diagnostic findings
    Secretin testAbnormalAbnormal
    Serum trypsinogenOften abnormalTypically normal
    Diffuse pancreatic calcifications on imagingFrequentInfrequent
    ERCPOften considerably abnormalMinimally abnormal to normal
Natural history
    Progression to steatorrhoeaFrequentRare
Pain therapy
    Pancreatic enzymesPoor to fair responseGood to excellent response
    Surgical proceduresSometimes helpfulUsually not indicated