Clinical manifestations
| Mucocutaneous ulceration (80%–100%) | Oral aphthous ulcers,1 genital ulcers |
| Cutaneous (35%–65%) | Pathergy,2 erythema nodosum, thrombophelibitis, acneiform skin eruption, palpable purpura |
| Ocular (50%–79%) | Anterior uveitis, posterior uveitis, corneal ulceration, conjunctivitis, papillitis, retinal vasculitis |
| Musculoskeletal (30–50%) | Non-erosive asymmetric oligoarthritis, pseudopodagra, sacroiliitis |
| Neurological (10%–30%) | Aseptic meningitis, encephalitis, peripheral Neuropathy, cranial nerve palsies, seizures, cerebellar ataxia, pseudobulbar palsy, extra pyramidal signs |
| Renal | Focal proliferative glomerulonephritis, diffuse proliferative glomerulonephritis, membranous glomerulonephritis |
| Cardiovascular | Pericarditis, myocarditis, coronary arteritis, conduction defects, endocarditis, endomyocardial fibrosis, intracranial aneurysms3 |