Interactions of psychotropic and cardiac medications: interactions involving tricyclic antidepressants and serotonergic antidepressants
| Medication | Effect on cardiac agent |
|---|---|
| Interactions involving tricyclic antidepressants | |
| Type Ia antiarrhythmics | Potentiate delay in cardiac conduction; heart block |
| Antihypertensives: guanethidine, clonidine, reserpine | Antagonise antihypertensive effect; potentiate orthostatic hypotension |
| Sublingual nitrates | Oral absorption hindered by dry mouth |
| α-Adrenergic blocking agents | Potentiate antihypertensive effect |
| Interactions involving serotonergic antidepressants | |
| Lipophilic β-blockers | Increase blood levels due to decreased hepatic degradation |
| Calcium channel blockers | |
| Type Ic antiarrhythmics | |
| Angiotensin converting enzyme inhibitors | |
| Warfarin | |
| Digitoxin | Increase bioavailability due to displacement from protein-binding sites |