Table 2

 Commonly used antidepressants, dosages, general and cardiovascular side effects

AgentStarting doseMaximum doseGeneral side effectsCardiovascular effects
Serotonin reuptake inhibitors
    Sertraline12.5–25 mg/day200 mg/daySexual dysfunction, nausea, diarrhoea, headacheBenign bradycardia
    Fluoxetine5–10 mg/day80 mg/dayAnxiety, agitation, insomnia, somnolence, sedation
    Paroxetine10 mg/day50 mg/dayTremor
Tricyclics
    Amitriptyline10–25 mg at bedtime300 mg/daySedation, somnolence, dry mouth, blurry visionIncrease QT, PR, QRS intervals, decreased T wave amplitude
    Imipramine10–25 mg at bedtime300 mg/dayConstipation, urinary retentionTachycardia, arrhythmias
    Nortriptyline10 mg/day150 mg/dayAnxiety, insomnia, weight gainPostural hypotension
    Desipramine25 mg/day300 mg/day
Psychostimulants
    Methylphenidate2.5 mg twice a day20 mg twice a dayAnxiety, agitation, insomniaTachycardia (mild), hypertension (mild)
Anorexia, paranoia
Other agents
    Bupropion75 mg/day150 mg three times a dayAnorexia, nausea, anziety, agitation, insomnia, seizures
    Venlafaxine12.5 mg twice a day125 mg three times a dayHeadache, sexual dysfunction, anxiety, insomnia, somnolence, dizzinessHypertension (dose related)
    Trazadone25 mg/day600 mg/daySedation, nausea, headache, priapism (rare)Postural hypotension, arrhythmias (rare)
    Mirtazapine15 mg every hour of sleep45 mg every hour of sleepSedation, somnolence, dry mouth, anticholinergic effects, dizziness agranulocytosis (rare)