Protein binding and clearance of AEDs
| % Protein binding | Clearance | |
|---|---|---|
| Tiagabine | 96 | liver |
| Phenytoin | 90 | liver |
| Valproate | 90 | liver |
| Clonazepam | 86 | liver |
| Carbamazepine | 75 | liver |
| Lamotrigine | 55 | liver |
| Phenobarbitone | 45 | liver/renal |
| Oxcarbazepine | 40 | liver |
| Topiramate | 15 | liver |
| Levetiracetam | 10 | renal |
| Gabapentin | 0 | renal |
| Vigabatrin | 0 | renal |
| Pregabalin | 0 | renal |