Table 1

 Protein binding and clearance of AEDs

% Protein bindingClearance
Tiagabine96liver
Phenytoin90liver
Valproate90liver
Clonazepam86liver
Carbamazepine75liver
Lamotrigine55liver
Phenobarbitone45liver/renal
Oxcarbazepine40liver
Topiramate15liver
Levetiracetam10renal
Gabapentin0renal
Vigabatrin0renal
Pregabalin0renal