Table 5

Demographic and haemodynamic clusterings of relative responsiveness to monotherapy according to antihypertensive drug class (modified from Dzau30)

FactorDiureticsβ-Blockersα1-BlockersACE inhibitors or AII receptor antagonistsCalcium antagonists
AII, angiotensin II; ACE, angiotensin converting enzyme; +, less effective than comparison group; ++, as effective as comparison group; +++, more effective than comparison group.
Age (older v younger)+++++++++++
Race (black v white)+++++++++++
Volume dependency (v not)+++++++++
Renin (high v low)+++++++++
Sympathetic activity (high v low)+++++++++++