Table 3

Evidence supporting association between NSAID use and complicated diverticular disease

StudyStudy designCasesControlsRelative risk/odds ratio and 95% CI for NSAID use
CI, confidence interval.
Wilson et al63Case-control92 patients with complicated diverticular disease. Inflammatory and bleeding complications92 Community based11.2 (7.1 to 17.5)
306 Colorectal cancer patients 6.6 (3.6 to 12.0)
Corder et al64Case-control115 patients with diverticular disease/extracolonic sepsis77 patients with diverticular disease and no extracolonic sepsis 4.9 (1.6 to 14.8)
Langman et al65Case-control107 patients with small or large bowel perforation107 patients with uncomplicated bowel disease 2.6 (1.6 to 4.1)
Campbell et al66Case-control50 patients with severe complications of diverticular disease50 emergency hospital admissions 4.2 (1.7 to 10.4)
50 patients with uncomplicated diverticular disease 3.7 (1.5 to 9.0)
Aldoori et al67Cohort: 35625 male health professionals310 self reported symptomatic diverticular disease 2.2 (1.3 to 3.9)