Clinical and laboratory features in 15 patients with bone disease in association with coeliac disease
| Patient | Sex | Age (years) | Skeletal abnormality | Phosphate (mmol/l) | Calcium (mmol/l) | Alkaline phosphatase (IU/l) | iPTH (IU/l) | 25-OH vit D (IU/l) |
Lumbar spine T score |
| 1 | F | 66 | Bone pain; myopathy | 1.06 | 2.25 | 289 | 143.0 | 2.8 | −4.44 |
| 2 | M | 43 | Fracture T 7 | 1.25 | 2.31 | 85 | 2.9 | 12 | −2.6 |
| 3 | F | 57 | Multiple vertebral fractures | 0.97 | 2.18 | 126 | −4.0 | ||
| 4 | F | 63 | Colle's fracture; back pain; myopathy | 0.58 | 2.65 | 1602 | >1000 | −0.7 | |
| 5 | F | 61 | Fractured neck of femur | 0.85 | 2.26 | 82 | −1.5 | ||
| 6 | F | 44 | Fractured shaft of femur; Colle's fracture | 1.22 | 2.17 | 99 | 17.5 | 6.9 | −2.6 |
| 7 | F | 77 | Fractured neck of femur | 1.49 | 2.12 | 113 | −2.8 | ||
| 8 | F | 35 | Multiple spine fractures | 1.4 | 2.02 | 114 | 5.3 | −3.67 | |
| 9 | F | 59 | T 10 fracture | 0.9 | 2.24 | 224 | −4.7 | ||
| 10 | F | 42 | Multiple fractures in childhood | 1.05 | 2.45 | 87 | 13.3 | −1.4 | |
| 11 | F | 37 | Asymptomatic, but severe osteoporosis | 1.17 | 2.14 | 74 | 3 | 33 | −3.2 |
| 12 | F | 38 | Asymptomatic, but severe osteoporosis | 0.96 | 2.59 | 42 | 1 | 35 | −3.11 |
| 13 | M | 64 | Colle's fracture | 1.28 | 2.1 | 75 | 8.2 | 7.7 | −3.43 |
| 14 | F | 54 | Pathological fracture of radius | 1.0 | 2.3 | 94 | 17 | −3.17 | |
| 15 | F | 55 | Colle's fracture | 1.3 | 2.16 | 78 | −2.9 |
In patients 1–8, bone disease was part of the presenting syndrome of coeliac disease.
Normal ranges for laboratory values: phosphate, 0.8–1.5 mmol/l; calcium, 2.2–2.7 mmol/l; alkaline phosphatase, 21–92 IU/l; immunoreactive parathyroid hormone (iPTH), < 4.3 IU/l; 25-hydroxy vitamin D (25-OH vit D), 4–40 IU/l; T score, lumbar spine and femur, > –2.5.