Table 1

Clinical and laboratory features in 15 patients with bone disease in association with coeliac disease

Patient Sex Age (years) Skeletal abnormality Phosphate (mmol/l) Calcium (mmol/l) Alkaline phosphatase (IU/l) iPTH (IU/l) 25-OH vit D (IU/l) Lumbar
spine T score
1F66Bone pain; myopathy1.062.25289143.02.8−4.44
2M43Fracture T 71.252.31852.912−2.6
3F57Multiple vertebral fractures0.972.18126−4.0
4F63Colle's fracture; back pain; myopathy0.582.651602>1000−0.7
5F61Fractured neck of femur0.852.2682−1.5
6F44Fractured shaft of femur; Colle's fracture1.222.179917.56.9−2.6
7F77Fractured neck of femur1.492.12113−2.8
8F35Multiple spine fractures1.42.021145.3−3.67
9F59T 10 fracture0.92.24224−4.7
10F42Multiple fractures in childhood1.052.458713.3−1.4
11F37Asymptomatic, but severe osteoporosis1.172.1474333−3.2
12F38Asymptomatic, but severe osteoporosis0.962.5942135−3.11
13M64Colle's fracture1.282.1758.27.7−3.43
14F54Pathological fracture of radius1.02.39417−3.17
15F55Colle's fracture1.32.1678−2.9
  • In patients 1–8, bone disease was part of the presenting syndrome of coeliac disease.

  • Normal ranges for laboratory values: phosphate, 0.8–1.5 mmol/l; calcium, 2.2–2.7 mmol/l; alkaline phosphatase, 21–92 IU/l; immunoreactive parathyroid hormone (iPTH), < 4.3 IU/l; 25-hydroxy vitamin D (25-OH vit D), 4–40 IU/l; T score, lumbar spine and femur, > –2.5.