Table 1

Features of major thyroid autoantigens

TSH receptor Sodium iodide symporter Thyroid peroxidase Thyroglobulin
Chromosome141928
Amino acids743643933274
ProteinG proteinTransmembrane transporterHaemoprotein enzymeIodinated glycoprotein
MW (kDa)8565–77105–110660
Glycosylation+++
FunctionReceptor for TSHIodide uptakeIodination and coupling of  tyrosineStorage of thyroxine +  triiodothyronine
HomologiesFSH + LH receptorNa/glucose transporterMyeloperoxidaseAnticholinesterase
  • FSH = follicle stimulating hormone; LH = luteinising hormone; MW=molecular weight.