Table 1

Recommendations for management of carriers or BRCA1 and BRCA2 gene mutations (adapted from Burke et al12 )

Topic Recommendation (expert opinion)
Breast self examinationEducation regarding monthly examination
Clinical breast examinationAnnually beginning at age 25–35
MammographyAnnually beginning at age 25–35
Transvaginal ultrasound
(with colour Doppler)
Annually beginning at age 25–35
Bilateral mastectomyInsufficient evidence to recommend for or against1-150
Bilateral oophorectomyInsufficient evidence to recommend for or against
Oestrogen replacementInsufficient evidence to recommend for or against1-150
Chemoprevention (for example, tamoxifen)Insufficient evidence to recommend for or against1-150
  • 1-150 There is evidence that these interventions may reduce the risk of cancer in individuals at high risk of breast or ovarian cancer, but data specific to patients with BRCA mutations are lacking.