Drugs used for postmenopausal hormone replacement therapy
Oestrogen | Type | Average daily dose |
Oral | Micronised oestradiol | 2 mg |
Conjugated oestrogens | 0.625 mg | |
Oestradiol valerate | 2 mg | |
Piperazine oestrone sulphate | 0.625 mg | |
Transdermal | Oestradiol in adhesive matrix or reservoir patch | 50 μg |
Oestradiol in a gel formulation | 2.5 g | |
Subcutaneous pellets | Administered at six monthly intervals | 50 mg |
Vaginal applications | These are administered daily for three weeks followed by twice weekly administration to minimise unopposed oestrogen effect on the uterus | |
Oestriol cream | ||
Oestradiol vaginal tablets | ||
Conjugated equine oestrogen cream | ||
Progestational agents | Average daily dose (sequential regimen) | |
Micronised progesterone | 300 mg | |
19-Nortestosterone derivatives | ||
Norethisterone | 1 mg | |
Levonorgestrel | 0.075 mg | |
Norgestrel | 0.150 mg | |
17 Acetoxy derivatives of progesterone: medroxyprogesterone acetate | 10 mg | |
C-21 Progestin: dydrogesterone | 10–20 mg | |
Other synthetic compounds | ||
Tibolone | 2.5 mg | |
Raloxifene | 60 mg |