Table 2

Prognostic indices in PBC

Model Variables included Formula for calculation of index Method of application of index
European60 Bilirubin (μmol/l)R = (2.51 × Loge serum bilirubin) + (0.00069 × exp   (age-20)/10) − (0.05 × albumin) + (0.88 × cirrhosis) +
(0.68 × central cholestasis) + ( 0.52 × azathiopirine) + 3.09
Cross reference to graph
Age (years)
Albumin (g/l)
Prothrombin time (sec)
Central cholestasis2-150
Cirrhosis2-151
Azathioprine2-152
Mayo62 Bilirubin (mg/dl)R = (0.871 × loge serum bilirubin) − (2.53 × loge albumin) +  (0.039 × age) + (0.859 × oedema) e Probability of survival of time t = Sexp (R—4..07)
Age (years)where S =0.970 at 1 year
Albumin (g/dl)0.941 at 2 years
Prorthrombin time (sec)0.774 at 5 years
Oedema2-153
Japanese63 Age (years)PI = (0.0409 × age) + (0.7801 × loge serum bilirubin) −   (0.8016 × loge albumin) + (0.3217 × log total serum cholesterol)Cross reference to graph
Bilirubin (mg/dl)
Albumin (g/dl)
Cholesterol (mg/dl)
  • 2-150 0 if central cholestasis absent on histology, 1 if present.

  • 2-151 0 if non-cirrhotic on histology, 1 if cirrhotic.

  • 2-152 0 if no azathioprine treatment, 1 if treated.

  • 2-153 0 if no oedema, 0.5 if oedema repsonsive to diuretics, 1 if non-resposive oedema.

  • PI=prognostic index.