RT Journal Article
SR Electronic
T1 Association between pulse pressure and ischaemic stroke in elderly patients with hypertension
JF Postgraduate Medical Journal
JO Postgrad Med J
FD The Fellowship of Postgraduate Medicine
SP 222
OP 226
DO 10.1136/postgradmedj-2019-137357
VO 97
IS 1146
A1 Jiayi Huang
A1 Lin Liu
A1 Yu-Qing Huang
A1 Kenneth Lo
A1 Yu-Ling Yu
A1 Chao-Lei Chen
A1 Song-tao Tang
A1 Bin Zhang
A1 Ying Qing Feng
YR 2021
UL http://pmj.bmj.com/content/97/1146/222.abstract
AB Background The association between pulse pressure (PP) and the risk of first ischaemic stroke (IS) is inconsistent. Therefore, we evaluated the association between PP and the risk of first IS among elderly hypertensive population in China.Methods This was a retrospective cohort study. Patients with hypertension and aged ≥60 years were recruited. Multivariate Cox regression was performed to evaluate the association between PP and the risk of IS. We further stratified the regression models into subgroups and test for interaction to assess whether the associations were modified by other covariates.Results A total of 3315 patients with hypertension (44.49% male; mean age 71.41±7.20 years) were included, and 206 cases of IS occurred with a median follow-up of 5.5 years. The results showed that per SD mm Hg increment in PP was associated with a 17% (95% CI 1.05 to 1.40, p=0.0172) increased risk of IS. Moreover, the HR of IS for the highest quartile of PP was 1.46 (95% CI 1.18 to 1.73, p=0.0011, p for trend <0.001) comparing with the lowest quartile of PP. Subgroup analysis showed that population aged ≥70 years, male, patients with smoking or drinking habit, diabetes at baseline, being overweight, with uncontrolled blood pressure or did not take antihypertensive drugs have a higher risk for IS.Conclusions We found that PP was significantly associated with IS and was an independent risk factor for IS.