RT Journal Article
SR Electronic
T1 Republished: Tracing PAKs from GI inflammation to cancer
JF Postgraduate Medical Journal
JO Postgrad Med J
FD The Fellowship of Postgraduate Medicine
SP 657
OP 668
DO 10.1136/postgradmedj-2014-306768rep
VO 90
IS 1069
A1 Dammann, Kyle
A1 Khare, Vineeta
A1 Gasche, Christoph
YR 2014
UL http://pmj.bmj.com/content/90/1069/657.abstract
AB P-21 activated kinases (PAKs) are effectors of Rac1/Cdc42 which coordinate signals from the cell membrane to the nucleus. Activation of PAKs drive important signalling pathways including mitogen activated protein kinase, phospoinositide 3-kinase (PI3K/AKT), NF-κB and Wnt/β-catenin. Intestinal PAK1 expression increases with inflammation and malignant transformation, although the biological relevance of PAKs in the development and progression of GI disease is only incompletely understood. This review highlights the importance of altered PAK activation within GI inflammation, emphasises its effect on oncogenic signalling and discusses PAKs as therapeutic targets of chemoprevention.