RT Journal Article SR Electronic T1 Republished paper: The quest to eliminate intrathecal vincristine errors: a 40-year journey JF Postgraduate Medical Journal JO Postgrad Med J FD The Fellowship of Postgraduate Medicine SP 71 OP 74 DO 10.1136/qshc.2008.030874rep VO 87 IS 1023 A1 Noble, Douglas J A1 Donaldson, Liam J YR 2011 UL http://pmj.bmj.com/content/87/1023/71.abstract AB Background Intrathecal administration of vincristine is a rare event but catastrophic for the patient, family and clinical team involved. Analysis of this source of harm shows it to be a classic systems error which has proved intractable for nearly 40 years. Failure to learn from history, communicate safety solutions nationally and internationally, create safety agencies which effectively and reliably prevent adverse events, conduct investigations and enquiries which fully reveals how to mitigate system error, develop robust physical design solutions to prevent harm to patients, make effective solutions universal and preparing for the unexpected are all major challenges.Conclusions The elimination of rare yet catastrophic errors like this remains one of the tests of whether we can make healthcare safer. In this paper, we discuss why effective learning has been so slow and illustrate lessons for other fields of patient safety.