RT Journal Article
SR Electronic
T1 Presentation of a PTHrP-secreting pancreatic neuroendocrine tumour, with hypercalcaemic crisis, pre-eclampsia, and renal failure
JF Postgraduate Medical Journal
JO Postgrad Med J
FD The Fellowship of Postgraduate Medicine
SP 752
OP 753
DO 10.1136/pmj.78.926.752
VO 78
IS 926
A1 P Abraham
A1 S H Ralston
A1 M Hewison
A1 W D Fraser
A1 J S Bevan
YR 2002
UL http://pmj.bmj.com/content/78/926/752.abstract
AB Severe hypercalcaemia during pregnancy is rare and most cases are secondary to hyperparathyroidism. This is the first report of a parathyroid hormone related protein (PTHrP) secreting neuroendocrine tumour of the pancreas manifesting with severe hypercalcaemia during pregnancy. Measurement of PTHrP was useful in both the diagnosis and follow up of our patient and should be considered in the diagnostic workup of patients with unexplained hypercalcaemia. A raised PTHrP concentration is a strong indicator of malignancy.