PT  - JOURNAL ARTICLE
AU  - P Abraham
AU  - S H Ralston
AU  - M Hewison
AU  - W D Fraser
AU  - J S Bevan
TI  - Presentation of a PTHrP-secreting pancreatic neuroendocrine tumour, with hypercalcaemic crisis, pre-eclampsia, and renal failure
AID  - 10.1136/pmj.78.926.752
DP  - 2002 Dec 01
TA  - Postgraduate Medical Journal
PG  - 752--753
VI  - 78
IP  - 926
4099  - http://pmj.bmj.com/content/78/926/752.short
4100  - http://pmj.bmj.com/content/78/926/752.full
SO  - Postgrad Med J2002 Dec 01; 78
AB  - Severe hypercalcaemia during pregnancy is rare and most cases are secondary to hyperparathyroidism. This is the first report of a parathyroid hormone related protein (PTHrP) secreting neuroendocrine tumour of the pancreas manifesting with severe hypercalcaemia during pregnancy. Measurement of PTHrP was useful in both the diagnosis and follow up of our patient and should be considered in the diagnostic workup of patients with unexplained hypercalcaemia. A raised PTHrP concentration is a strong indicator of malignancy.