RT Journal Article SR Electronic T1 Fatigue in cholestatic liver disease—a perplexing symptom JF Postgraduate Medical Journal JO Postgrad Med J FD The Fellowship of Postgraduate Medicine SP 404 OP 407 DO 10.1136/pmj.78.921.404 VO 78 IS 921 A1 Kumar, D A1 Tandon, R K YR 2002 UL http://pmj.bmj.com/content/78/921/404.abstract AB Fatigue is an important symptom and a quality of life determinant in patients with cholestatic liver disease. The pathogenesis of fatigue is obscure, although alterations in central neurotransmission and peripheral muscle dysfunction have been incriminated. No effective treatment is available at present. The available literature on fatigue in cholestatic liver disease is reviewed.