PT  - JOURNAL ARTICLE
AU  - Stewart, Andrew J
AU  - Penman, Ian D
AU  - Cook, Margaret K
AU  - Ludlam, Christopher A
TI  - Warfarin-induced skin necrosis
AID  - 10.1136/pgmj.75.882.233
DP  - 1999 Apr 01
TA  - Postgraduate Medical Journal
PG  - 233--235
VI  - 75
IP  - 882
4099  - http://pmj.bmj.com/content/75/882/233.short
4100  - http://pmj.bmj.com/content/75/882/233.full
SO  - Postgrad Med J1999 Apr 01; 75
AB  - Skin necrosis is a rare but serious side-effect of treatment with warfarin. At particular risk are those with various thrombophilic abnormalities, especially when warfarinisation is undertaken rapidly with large loading doses of warfarin. With the increasing number of patients anticoagulated as out-patients for thromboprophylaxis, we are concerned that the incidence of skin necrosis may increase. If skin necrosis does occur, prompt remedial action may be of benefit in preventing permanent tissue damage.