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Disorders of gut-brain interaction in post-acute COVID-19 syndrome
  1. Rithvik Golla,
  2. Sudheer Kumar Vuyyuru,
  3. Bhaskar Kante,
  4. Saurabh Kedia,
  5. Vineet Ahuja
  1. Gastroenterology and Human Nutrition, All India Institute of Medical Sciences, New Delhi, Delhi, India
  1. Correspondence to Dr Vineet Ahuja, Gastroenterology and Human Nutrition, All India Institute of Medical Sciences, New Delhi, Delhi, India; vineet.aiims{at}


The novel coronavirus SARS-CoV-2 is responsible for the devastating pandemic which has caused more than 5 million deaths across the world until today. Apart from causing acute respiratory illness and multiorgan dysfunction, there can be long-term multiorgan sequalae after recovery, which is termed ‘long COVID-19’ or ‘post-acute COVID-19 syndrome’. Little is known about long-term gastrointestinal (GI) consequences, occurrence of post-infection functional gastrointestinal disorders and impact the virus may have on overall intestinal health. In this review, we put forth the various mechanisms which may lead to this entity and possible ways to diagnose and manage this disorder. Hence, making physicians aware of this spectrum of disease is of utmost importance in the present pandemic and this review will help clinicians understand and suspect the occurrence of functional GI disease post recovery from COVID-19 and manage it accordingly, avoiding unnecessary misconceptions and delay in treatment.

  • functional bowel disorders
  • COVID-19
  • motility disorders
  • gastrointestinal infections

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  • Contributors RG: Drafted the manuscript. SKV: Drafted and reviewed the manuscript. BK: Reviewed the manuscript. SK: Reviewed the manuscript. VA: Concept of manuscript and reviewed the manuscript.

  • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

  • Competing interests None declared.

  • Provenance and peer review Not commissioned; externally peer reviewed.