Purpose The relation between hospitalization timing and risk of clinical outcomes among patients with atrial fibrillation (AF) with and without stroke remained undetermined.
Methods Rehospitalization due to AF, cardiovascular (CV) death and all-cause mortality were the outcomes of interest in this study. Multivariable Cox proportional hazard model was applied to estimate the adjusted hazard ratio (HR) and 95% confidence interval (CI).
Results While considering patients with AF hospitalized during weekdays without stroke as the reference group, patients with AF hospitalized during weekends with stroke had the risk of AF rehospitalization, CV death and all-cause death by 1.48 (95% CI 1.44 to 1.51), 1.77 (95% CI 1.71 to 1.83) and 1.17 (95% CI 1.15 to 1.19) times, respectively.
Conclusion Patients with AF hospitalized during weekends with stroke had the worst clinical outcomes.
Data availability statement
No data are available.
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Contributors All authors contributed to the manuscript. All were involved in the design of the study, collected the data, statistical analysis, wrote the manuscript and all authors were involved in the final approval of the manuscript.
Funding This study was supported in part by Taiwan Ministry of Health and Welfare Clinical Trial Centre (MOHW109-TDU-B-212-114004), China Medical University (CMU110-AWARD-01) and China Medical University Hospital (DMR-HHC-110-4).
Competing interests None declared.
Provenance and peer review Not commissioned; externally peer reviewed.