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Development process and clinical application of collagenase chemonucleolysis in the treatment of lumbar disc herniation: a narrative review in China
  1. Peng Yuan1,
  2. Xiaohua Shi2,
  3. Xuanjun Wei3,
  4. Zijun Wang4,
  5. Jiao Mu1,5,6,
  6. Hongxin Zhang1
  1. 1Interventional Radiology and Pain Treatment, The Second Affiliated Hospital of Air Force Medical University, Air Force Medical University, Xi'an, China
  2. 2Xi'an Medical University, Xi'an, China
  3. 3The 3rd clinical department of China Medical University, China Medical University, Shenyang, China
  4. 4Battalion of the first Regiment of cadets of Basic Medicine, Air Force Military Medical University, Xi'an, China
  5. 5Hematology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China
  6. 6Hematology, Xi'an Central Hospital, Xi'an, China
  1. Correspondence to Ms Jiao Mu, The First Affiliated Hospital of Chongqing Medical University, Chongqing, Sichuan, China; fzzxmj{at}; Mr Hongxin Zhang; zhhxtdjr{at}


Lumbar disc herniation (LDH) is one of the most common causes of lumbocrural pain. In the past 20 years, the incidence of LDH has increased dramatically. There are many treatments for LDH, including conservative treatment (such as acupuncture and physiotherapy), minimally invasive interventional treatment (such as collagenase chemonucleolysis and radiofrequency ablation) and surgical treatment. The main purpose of this paper is to review the development process and application status of collagenase chemonucleolysis in the treatment of LDH at home and abroad and provide a reference for clinical treatment.

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  • PY and XS are joint first authors.

  • PY and XS contributed equally.

  • Contributors PY and HXS contributed to the conception and design of the work, drafting and editing. JM and XHZ contributed to the drafting, revision and final submission of the manuscript. JXW and JZW contributed to the revision and design of the image. All the contributors were involved in revising the final version and granting final approval for the article to be submitted for publication.

  • Funding This work was supported by the National Natural Science Foundation of China (grant 81802345), China Postdoctoral Science Foundation-funded project (grants 2019M663984 and 2020T130787), and National Science Basic Research Plan in Shaanxi Province of China (grants 2020JM-318, 2020JM-327 and 2021JM-241).

  • Competing interests None declared.

  • Provenance and peer review Not commissioned; externally peer reviewed.