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rs10865710 polymorphism in PPARG promoter is associated with the severity of type 2 diabetes mellitus and coronary artery disease in a Chinese population
  1. Yongyan Song1,
  2. Tariq Muhammad Raheel2,
  3. Aimei Jia3,
  4. Guowei Dai4,
  5. Liang Liu4,
  6. Xiaobin Long4,
  7. Chuan He4
  1. 1Central Laboratory, and Medical Key Laboratory of Clinical Genetics of Sichuan Province, Affiliated Hospital of Chengdu University, Chengdu, Sichuan, People's Republic of China
  2. 2Department of Cardiology, Affiliated Hospital of North Sichuan Medical College, Nanchong, Sichuan, People's Republic of China
  3. 3Department of General Surgery, Affiliated Hospital of North Sichuan Medical College, Nanchong, Sichuan, People's Republic of China
  4. 4Department of Cardiology, Affiliated Hospital of Chengdu University, Chengdu, Sichuan, People's Republic of China
  1. Correspondence to Professor Chuan He, Department of Cardiology, Affiliated Hospital of Chengdu University, Chengdu, Sichuan, People's Republic of China; hechuancdu{at}qq.com

Abstract

Background Relationship between polymorphisms in peroxisome proliferator-activated receptor gamma (PPARG) and progression of type 2 diabetes mellitus (T2DM) and coronary artery disease (CAD) remains to be clarified.

Methods 635 subjects were divided into T2DM, CAD, T2DM complicated with CAD (T2DM/CAD) and control groups according to diagnostic criteria. The rs10865710 and rs3856806 polymorphisms were genotyped, and the severity of T2DM and CAD was evaluated for all subjects.

Results In patients with T2DM, G allele carriers of rs10865710 polymorphism had significantly higher levels of glucose, triglycerides, apolipoprotein B (ApoB) and lipoprotein (a) (Lp(a)) than non-carriers, T allele carriers of rs3856806 polymorphism had significantly higher levels of glucose, low-density lipoprotein cholesterol (LDL-C), ApoB and Lp(a) than non-carriers. In patients with CAD, G allele carriers of rs10865710 polymorphism had significantly higher levels of total cholesterol (TC), ApoB and Lp(a) than non-carriers, T allele carriers of rs3856806 polymorphism had significantly higher levels of body mass index, blood pressure, TC, LDL-C and ApoB than non-carriers. Patients with one or two G alleles of rs10865710 polymorphism had significantly higher levels of Gensini scores and more diseased coronary branches than those patients without CAD. The rs3856806 polymorphism was not associated with CAD severity, but it was found to be significantly associated with T2DM/CAD, T allele frequency was significantly higher in T2DM/CAD group than that in T2DM/CAD-free group.

Conclusions The rs10865710 and rs3856806 polymorphisms in PPARG are significantly associated with glucose levels in patients with T2DM. The rs10865710 polymorphism is significantly associated with the severity of CAD, which is possibly mediated by hyperlipidaemia and hyperglycaemia.

  • coronary heart disease
  • general diabetes
  • genetics

Data availability statement

All data relevant to the study are included in the article or uploaded as supplemental information.

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Data availability statement

All data relevant to the study are included in the article or uploaded as supplemental information.

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Footnotes

  • Contributors CH and YS conceived of the study, participated in the design and drafted the manuscript. TMR and AJ extracted DNA and genotyped the rs10865710 and rs3856806 polymorphisms. GD, LL and XL collected the clinical data. YS performed the statistical analysis. All authors reviewed and approved the final manuscript.

  • Funding This research was supported by grants from Medical Key Laboratory of Clinical Genetics of Sichuan Province (KL012).

  • Competing interests None declared.

  • Provenance and peer review Not commissioned; externally peer reviewed.

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