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Claustrum hyperintensity as a marker of anti-NMDAR encephalitis
  1. Amlan Kusum Datta1,
  2. Uddalak Chakraborty1,
  3. Arpan Dutta1,
  4. Sudeshna Malakar2,
  5. Alak Pandit1
  1. 1Neurology, Institute of Postgraduate Medical Education and Research Bangur Institute of Neurology, kolkata, West Bengal, India
  2. 2Radiodiagnosis, Apollo Gleneagles Hospital, Kolkata, West Bengal, India
  1. Correspondence to Uddalak Chakraborty, Neurology, Institute of Postgraduate Medical Education and Research Bangur Institute of Neurology, kolkata 700020, West Bengal, India; uddaalakchakraborty{at}gmail.com

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A young adult male patient presented with subacute onset, rapidly progressive cognitive impairment and refractory seizures and was diagnosed as definite anti N-methyl D-aspartate receptor (anti-NMDAR) antibody encephalitis as per criteria by Graus et al. (2016), following detection of culprit autoantibodies in serum.1 MRI of brain revealed bilateral T2-weighted image (T2WI)/fluid-attenuated inversion recovery (FLAIR) claustrum hyperintensities (figure 1). Previously, in a cohort of 34 patients,2 presenting with new-onset refractory epilepsy, 4 out of 34 patients showed bilateral claustrum FLAIR hyperintensities on MRI imaging, …

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Footnotes

  • Contributors AKD and UC drafted the initial manuscript and collaborated in diagnosis and management of the patient; AD and SM collected the images, worked for critical content and revision of manuscript with review of literature; AP supervised the entire procedure and treatment of the patient.

  • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

  • Competing interests None declared.

  • Provenance and peer review Not commissioned; externally peer reviewed.

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