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Hypothermia induced by quetiapine
  1. Ami Schattner1,2,
  2. Ina Dubin2
  1. 1Faculty of Medicine, Hebrew University Hadassah Medical School, Jerusalem, Israel
  2. 2Department of Medicine, Laniado Hospital, Sanz Medical Centre, Netanya, Israel
  1. Correspondence to Professor Ami Schattner, Hebrew University Hadassah Medical School, Yerushalayim 91120, Israel; amischatt{at}gmail.com

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An 89-year-old woman was brought to the emergency department, responding only to pain (GCS 6), with a rectal temperature of 28.5°C, hypotension (68/40), bradycardia (35/min) and bradypnoea. The remainder of the examination was unremarkable.

She was living at home with her son and a caretaker, confined to bed/wheelchair with a history of Alzheimer’s dementia, falls, hypothyroidism (on replacement), hypertension and chronic atrial fibrillation (AF) (on amlodipine 5 mg four times a day, propranolol 10 mg three times a day). Other regular medications included quetiapine (Seroquel) 125 mg four times a day and brotizolam 0.25 mg.

Laboratory tests showed no evidence of infection or metabolic disorder except acidosis (pH 7.27). Thyoid stimulating hormone (TSH) and cortisol levels were normal. Chest X-ray, head CT and urinalysis were unremarkable; ECG showed slow AF. …

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Footnotes

  • Contributors AS wrote the manuscript with the participation of ID. ID and AS planned the study. AS conducted a survey of the literature and composed the manuscript, aided by ID.

  • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

  • Competing interests None declared.

  • Patient consent for publication Next of kin consent obtained.

  • Provenance and peer review Not commissioned; externally peer reviewed.

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