Background Although hyperlipidaemia was a well-known risk factor for ischaemic stroke, the association between triglyceride and first ischaemic stroke remains uncertain.
Objectives The present study attempted to explore the relationship between triglyceride and first ischaemic stroke in a Chinese community elderly patients with hypertension.
Methods and results This was a retrospective cohort study. We enrolled 3249 consecutive elderly patients with hypertension from a community in China between January 2010 and December 2011. Patients were divided into four groups based on the quartiles of triglyceride. Multivariate Cox regression analysis, subgroup and interaction test were performed to evaluate the relationship between triglyceride and first ischaemic stroke. There were a total of 3249 participants including 1455 male and 1794 female, with a mean age of 71.36±7.18 years. At an average follow-up of 5.5 years, 205 patients were identified to have first ischaemic stroke. After adjustment for potential confounders, using the lowest quartiles of triglyceride as the reference, multivariable HR (95% CI) for first ischaemic stroke increased in parallel with the quartiles of triglyceride (HRs were 1.56 (95% CI 1.07 to 2.51), 1.74 (95% CI 1.07 to 2.84) and 1.85 (95% CI 1.05 to 2.89)) from the second to the fourth quartiles, respectively (p=0.002 for trend). Subgroup and interaction analysis showed that there was no interactive effect on triglyceride and first ischaemic stroke.
Conclusion Triglyceride was an independent risk factor for first ischaemic stroke among Chinese elderly patients with hypertension.
- ischemic stroke
- hypertensive patients
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Contributors Y-QH drafted the manuscript and helped with the statistical analysis. Y-QF and BZ participated in the design of the study and revised the manuscript. J-YH, LL, C-LC, Y-LY and S-TT participated in data collection. All authors read and approved the final manuscript.
Funding This work was supported by the Natural Science Foundation of Guangdong Province (No. 2015A030313660), the Science and Technology Program of Guangzhou (Nos. 201604020143, 201604020018, 201510010254 and 201803040012), the National Key Research and Development Program of China (Nos. 2017YFC1307603, 2016YFC1301305 and 2017YFC0909303) and the Key Area R&D Program of Guangdong Province (No. 2019B020227005).
Competing interests None declared.
Patient consent for publication Not required.
Ethics approval This study was in compliance with the principles outlined in the Declaration of Helsinki and was approved by the institutional medical ethical committee of the Guangdong General Hospital, Guangzhou, China.
Provenance and peer review Not commissioned; externally peer reviewed.
Data availability statement Data are available on reasonable request.
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